Zhang, L. L., Wei, W., Xiao, F., Xu, J. H., Bao, C. D., Ni, L. Q., and Li, X. F. A randomized, double-blind, multicenter, controlled clinical trial of chicken type II collagen in patients with rheumatoid arthritis. It is composed of three identical α-chains, that is, its α-chain composition is α1(II) 3. But there's no evidence that collagen type II can prevent joint space narrowing in people with osteoarthritis. But more research is needed to confirm. Collagen type II is POSSIBLY SAFE when taken by mouth in doses up to 2.5 mg daily for up to 24 weeks. Oral type II collagen in the treatment of rheumatoid arthritis. Oral collagen in the treatment of rheumatoid arthritis [editorial]. Collagen 2 is also found in vertebral disks, inner ear and the vitreous. Type II collagen. Thompson DJ, Barron KS, Whitcup SM, Robinson MR. © 2005 - 2019 WebMD LLC. Br J Rheumatol 1998;37(10):1110-1117. No doi View abstract. It's not clear what the side effects might be. Early research shows that taking collagen type II doesn't improve eye symptoms in children with uveitis related to juvenile rheumatoid arthritis. Treatment of rheumatoid arthritis with oral type II collagen. Collagen type II is a fibril-forming collagen that forms the bulk of the vitreous collagen fibrils, accounting for 60–75% of the collagen within the fibrils. Other collagen products, such as bovine collagen and gelatin, have caused allergic reactions. Ocul Immunol Inflamm. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. The best evidence suggests that taking collagen type II doesn't greatly improve symptoms of RA. Information from this source is evidence-based and objective, and without commercial influence. 2009 Oct 9;6(6):312-21. Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, et al Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. In fact, using it in place of drugs for RA such as methotrexate might make symptoms worse. This information may not fit your specific health circumstances. View abstract. Have you ever purchased COLLAGEN TYPE II (NATIVE)? Collagen type II is POSSIBLY SAFE when taken by mouth in doses up to 2.5 mg daily for up to 24 weeks. It might also help these people exercise for longer before feeling joint pain. View abstract. Most collagen type II in supplements comes from chicken. Type II collagen is the basis for articular cartilage and hyaline cartilage, formed by homotrimers of collagen, type II, alpha 1 chains. Most research has investigated a specific product called UC-II. Mullins RJ, Richards C, Walker T. Allergic reactions to oral, surgical and topical bovine collagen. Cazzola M, Antivalle M, Sarzi-Puttini P, Dell'Acqua D, Panni B, Caruso I. 2009;11(6):R180. (check all that apply), What factors are most important to you? At this time there is not enough scientific information to determine an appropriate range of doses for collagen type II. Arthritis Rheum 1996;39:623-8. What is type II collagen? The safety and efficacy of chicken type II collagen on uveitis associated with juvenile rheumatoid arthritis. Multi Collagen Hydrolyzed Protein Powder (16oz) - Types I, II, III, V & X - Grass Fed Bovine (Peptan®), Wild Caught Marine, Free Roaming Chicken & Eggshell Collagen Peptides, Non-GMO, GF. 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